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View BPC-157 / KPV / TB-500 Blend Table of contents The mechanism: why GLP-1 receptors in your colon matter The clinical data: how often constipation actually happens The GLP-1 gut motility paradox: why some get constipation and others get diarrhea What most articles get wrong about "slowed digestion" The three-phase constipation pattern: acute, adaptation, and resolution Symptoms that mean constipation vs symptoms that mean obstruction The step-up protocol: fiber, hydration, osmotic laxatives, and when to escalate Foods and supplements that worsen GLP-1 constipation The dose-response question: does higher dose mean worse constipation

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These agents may be used as first-line treatment in patients for whom metformin is not tolerated or is contraindicated, or in combination with other glucose-lowering agents, including insulin [2]

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